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Ekstrofi kandung kemih (bladder exstrophy) merupakan kondisi yang jarang terjadi.[3] Dikutip dari American Journal of Medical Genetics menemukan bahwa total prevalensi ekstrofi kandung。

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Bladder exstrophy is a congenital anomaly that exists along the spectrum of the exstrophy-epispadias complex, and most notably involves protrusion of the urinary bladder through a defect in the abdominal wall. Its presentation is variable, often including abnormalities of the bony pelvis, pelvic floor, and genitalia. The underlying embryologic mechanism leading to bladder exstrophy is unknown, though it is thought to be in part due to failed reinforcement of the cloacal membrane b…

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The history of folic acid. British journal of haematology, 113(3), 579–589. British journal of haematology, 113(3), 579–589. Ionescu-Ittu, R. et al. (2009).

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